Pharmacy Prescriptions, Gastrointestinal Meds

Uprima (Apomorphine)

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Treating loss of control of body movements such as muscle stiffness slow movements or trouble moving associated with advanced Parkinson disease. Uprima (Apomorphine) is a dopamine agonist. It works by stimulating dopamine receptors which helps improve motor function. Also used to treat erectile dysfunction.

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About Uprima (Apomorphine):

Product Type: Other

Brand name: Uprima Generic name: Apomorphine Uprima (Apomorphine) is used for: Treating loss of control of body movements such as muscle stiffness slow movements or trouble moving associated with advanced Parkinson disease. Uprima (Apomorphine) is a dopamine agonist. It works by stimulating dopamine receptors which helps improve motor function. Do NOT use Uprima (Apomorphine) if: • you are allergic to any ingredient in Uprima (Apomorphine) (especially a sulfite) • you have decreased consciousness seizures or very low blood pressure • you are taking a 5-HT3 antagonist antiemetic (eg ondansetron dolasetron granisetron palonosetron alosetron) Contact your doctor or health care provider right away if any of these apply to you. Before using Uprima (Apomorphine): Some medical conditions may interact with Uprima (Apomorphine). Tell your doctor or pharmacist if you have any medical conditions especially if any of the following apply to you: • if you are pregnant planning to become pregnant or are breast-feeding • if you are taking any prescription or nonprescription medicine herbal preparation or dietary supplement • if you have allergies to medicines foods or other substances • if you have had a severe allergic reaction (eg severe rash hives difficulty breathing dizziness) to sulfites • if you have a history of low blood pressure dizziness fainting irregular or slow heartbeat or a history of a certain type of irregular heartbeat (eg congenital QT prolongation) low blood magnesium or potassium levels asthma liver problems kidney problems heart problems mental or mood problems sleep problems (eg falling asleep without warning) or stroke or other brain problems • if you regularly drink alcohol or if you have a history of alcohol or substance abuse Some MEDICINES MAY INTERACT with Uprima (Apomorphine). Tell your health care provider if you are taking any other medicines especially any of the following: • 5-HT3 antagonist antiemetics (eg ondansetron) because the risk of severe low blood pressure and loss of consciousness may be increased • Antiarrhythmics (eg amiodarone quinidine sotalol) arsenic azole antifungals (eg ketoconazole) bepridil cisapride droperidol H1 antagonists (eg astemizole terfenadine) ketolides (eg telithromycin) macrolide antibiotics (eg erythromycin) phenothiazines (eg thioridazine) phosphodiesterase type 5 inhibitors (eg vardenafil) pimozide quinolone antibiotics (eg ciprofloxacin) serotonin receptor antagonist antiemetics (eg dolasetron) tricyclic antidepressants (eg imipramine) or ziprasidone because the risk of serious side effects such as abnormal heart rhythms may be increased • Medicine for high blood pressure nitroglycerin or vasodilators (eg isosorbide) because they may increase the risk of Uprima (Apomorphine)'s side effects • Butyrophenones (eg haloperidol) metoclopramide phenothiazines (eg chlorpromazine) or thioxanthenes (eg thiothixene) because they may decrease Uprima (Apomorphine)'s effectiveness This may not be a complete list of all interactions that may occur. Ask your health care provider if Uprima (Apomorphine) may interact with other medicines that you take. Check with your health care provider before you start stop or change the dose of any medicine. How to use Uprima (Apomorphine): Use Uprima (Apomorphine) as directed by your doctor. Check the label on the medicine for exact dosing instructions. • An extra patient leaflet is available with Uprima (Apomorphine). Talk to your pharmacist if you have questions about this information. • Uprima (Apomorphine) is usually given as an injection at your doctor's office hospital or clinic. If you will be using Uprima (Apomorphine) at home a health care provider will teach you how to use it. Be sure you understand how to use Uprima (Apomorphine). Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. • Uprima (Apomorphine) is for subcutaneous injection only. Do not inject Uprima (Apomorphine) into a vein. • Make sure you understand how to properly measure each dose of Uprima (Apomorphine) before injecting it. Ask your pharmacist for help if you are unsure of how to measure your dose. • Rotate sites where the medicine is injected. Do not always use the same site. • Do not inject medicine into a site that is sore red infected or damaged. • Do not use Uprima (Apomorphine) if it contains particles is cloudy or discolored or if the vial is cracked or damaged. • Your doctor may prescribe another medicine called an antiemetic before you start taking Uprima (Apomorphine) to lessen the nausea and vomiting that can occur when taking Uprima (Apomorphine). You may need to continue taking the antiemetic for the first 2 months of therapy. • Keep this product as well as syringes and needles out of the reach of children and pets. Do not reuse needles syringes or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal. • If you miss a dose of Uprima (Apomorphine) use it as soon as possible. If it is almost time for your next dose skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. Ask your health care provider any questions you may have about how to use Uprima (Apomorphine). Important safety information: • Uprima (Apomorphine) may cause drowsiness dizziness or cause you to fall asleep without warning. These effects may be worse if you take it with alcohol or certain medicines. Use Uprima (Apomorphine) with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. • Uprima (Apomorphine) may cause dizziness lightheadedness or fainting; alcohol hot weather exercise or fever may increase these effects. To prevent them sit up or stand slowly especially in the morning. Sit or lie down at the first sign of any of these effects. • Do not drink alcohol or use medicines that may cause drowsiness (eg sleep aids muscle relaxers) while you are using Uprima (Apomorphine); it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. • Do NOT use more than the recommended dose of Uprima (Apomorphine) or use it more often than prescribed without checking with your doctor. • Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients (eg asthma patients). If you have ever had an allergic reaction to sulfites ask your pharmacist if your product has sulfites in it. • Patients with Parkinson disease may have an increased risk of developing a certain type of skin cancer (melanoma). It is not known if Uprima (Apomorphine) also increases the risk of melanoma. You may need to have skin exams while you are using Uprima (Apomorphine). Tell your doctor if you notice any unusual skin growths or a change in the appearance of a mole. Discuss any questions or concerns with your doctor. • Some people have experienced new unusual or increased urges (eg gambling sexual urges) while using Uprima (Apomorphine). Tell your doctor right away if you notice such effects. • Uprima (Apomorphine) may rarely cause a prolonged painful erection. This could happen even when you are not having sex. If this is not treated right away it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. • Do not suddenly stop taking Uprima (Apomorphine). Doing so may cause withdrawal symptoms like fever; stiff muscles; confusion; abnormal thinking; and fast or irregular heartbeat. Check with your doctor before you change your dose or stop Uprima (Apomorphine). • Lab tests including skin exams may be performed while you use Uprima (Apomorphine). These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. • Use Uprima (Apomorphine) with caution in the ELDERLY; they may be more sensitive to its effects especially confusion and hallucinations. • Uprima (Apomorphine) should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. • PREGNANCY and BREAST-FEEDING: If you become pregnant contact your doctor. You will need to discuss the benefits and risks of using Uprima (Apomorphine) while you are pregnant. It is not known if Uprima (Apomorphine) is found in breast milk. Do not breast-feed while taking Uprima (Apomorphine). Some people who use Uprima (Apomorphine) for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. Possible side effects of Uprima (Apomorphine): All medicines may cause side effects but many people have no or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: • Bruising itching pain swelling or redness at the injection site; dizziness; drowsiness; flushing; headache; nausea; pale skin; runny nose; vomiting; yawning. Seek medical attention right away if any of these SEVERE side effects occur: • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth face lips or tongue); agitation; chest pain; confusion; difficulty moving; fainting; falling asleep without warning; falling down; fast or irregular heartbeat; hallucinations; increased sweating; mental or mood changes (eg depression); new unusual or increased urges (eg gambling sexual urges); painful or prolonged erection; severe dizziness nausea or vomiting; severe or persistent headache; shortness of breath; sudden uncontrollable movements; swelling of the arms hands legs or feet; unusual change in the appearance of a mole or other skin growths; vision changes. This is not a complete list of all side effects that may occur. If you have questions about side effects contact your health care provider. Call your doctor for medical advice about side effects. If OVERDOSE is suspected: Symptoms may include agitation; chest pain; confusion; difficulty moving; grogginess; lightheadedness especially when standing; loss of consciousness; severe nausea or vomiting; slow heartbeat. Proper storage of Uprima (Apomorphine): Store Uprima (Apomorphine) at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat moisture and light. Do not store in the bathroom. Keep Uprima (Apomorphine) out of the reach of children and away from pets.

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